Dr. Ikeda’s lecture on ubiquitin and ubiquitin like molecules in the regulation of signaling
Ubiquitin is a small molecule, so-named for its extraordinary wide distribution from yeast to man. The covalent ubiquitylation of proteins is a widespread regulatory post-translational modification, as like protein phosphorylation. Early interest in ubiquitylation centered on the role of polyubiquitin chains in targeting proteins for degradation. However, ubiquitin is now revealed to be involved in many biological functions.
Furthermore, the recent studies of ubiquitin like molecules (UBL), which have a similar folding as ubiquitin, give more focus of ubiquitin and UBL in the regulation of various signaling pathways. You will hear our recent data on ubiquitin and UBL especially in the regulation of NF-kB and interferon signaling pathways with short introduction of general concept of ubiquitin and UBLs during the talk.
Lecture by dr. Fumiyo Ikeda.