Predavanja

November 20th 2008, 4 pm, large lecture hall at MedILS

Natural substances may interact with numerous target proteins in human cells. For the flavonoid quercetin a method has been developed which allows the identification of unknown target proteins. The target proteins that have been of particular interest to us include the cytoskeletal proteins actin and tubulin and their associated motor proteins. New inhibitors for these proteins have been identified and the effect of the inhibitors studied in various cellular test systems. Possible medical applications will be discussed.

Interaction of natural substances with cellular target proteins (prof. dr. Herwig Gutzeit, TU Dresden, Germany)

Subcellular Min oscillations in E. coli: experimental and computational studies (Andrew Rutenberg, Dalhousie University, Canada)

Andrew Rutenberg Dalhousie University, Canada

MedILS, big lecture hall, July 11th 2008, 4 pm

Genomic principles for feedback regulation of metabolism

Nick Luscombe, PhD
European Bioinformatics Institute
Wellcome Trust Genome Campus
Cambridge, UK

MedILS, konferencijska sala, 17. lipanj 2008, 16:00 h

Dr. Ikeda’s lecture on ubiquitin and ubiquitin like molecules in the regulation of signaling

Ubiquitin is a small molecule, so-named for its extraordinary wide distribution from yeast to man. The covalent ubiquitylation of proteins is a widespread regulatory post-translational modification, as like protein phosphorylation. Early interest in ubiquitylation centered on the role of polyubiquitin chains in targeting proteins for degradation. However, ubiquitin is now revealed to be involved in many biological functions.