MedILS » Publikacije http://www.medils.org/hr Mediteranski institut za istraživanje života Mon, 18 Jul 2011 07:53:48 +0000 en hourly 1 http://wordpress.org/?v= Atypical ubiquitin chains: new molecular signals http://www.medils.org/hr/index.php/archives/2008/07/22/atypical-ubiquitin-chains-new-molecular-signals/ http://www.medils.org/hr/index.php/archives/2008/07/22/atypical-ubiquitin-chains-new-molecular-signals/#comments Tue, 22 Jul 2008 15:59:16 +0000 zeljka http://www.medils.org/hr/?p=343 Fumiyo Ikeda, Ivan Dikic, EMBO reports, 2008, 536-542

Atypical ubiquitin chains: new molecular signals

]]> http://www.medils.org/hr/index.php/archives/2008/07/22/atypical-ubiquitin-chains-new-molecular-signals/feed/ 0 Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction http://www.medils.org/hr/index.php/archives/2008/07/22/ubiquitin-docking-at-the-proteasome-through-a-novel-pleckstrin-homology-domain-interaction/ http://www.medils.org/hr/index.php/archives/2008/07/22/ubiquitin-docking-at-the-proteasome-through-a-novel-pleckstrin-homology-domain-interaction/#comments Tue, 22 Jul 2008 15:48:29 +0000 zeljka http://www.medils.org/hr/?p=341 Patrick Schreiner, Xiang Chen, Koraljka Husnjak, Leah Randles, Naixia Zhang, Suzanne Elsasser, Daniel Finley, Ivan Dikic, Kylie J. Walters & Michael Groll
Nature, 2008, 453:548-552

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

]]> http://www.medils.org/hr/index.php/archives/2008/07/22/ubiquitin-docking-at-the-proteasome-through-a-novel-pleckstrin-homology-domain-interaction/feed/ 0 Proteasome subunit Rpn13 is a novel ubiquitin receptor http://www.medils.org/hr/index.php/archives/2008/07/22/proteasome-subunit-rpn13-is-a-novel-ubiquitin-receptor/ http://www.medils.org/hr/index.php/archives/2008/07/22/proteasome-subunit-rpn13-is-a-novel-ubiquitin-receptor/#comments Tue, 22 Jul 2008 15:32:47 +0000 zeljka http://www.medils.org/hr/?p=338 Koraljka Husnjak, Suzanne Elsasser, Naixia Zhang, Xiang Chen, Leah Randles, Yuan Shi, Kay Hofmann, Kylie J. Walters, Daniel Finley, Ivan Dikic. Nature 453, 2008, 481-488
Proteasome subunit Rpn13 is a novel ubiquitin receptor

]]> http://www.medils.org/hr/index.php/archives/2008/07/22/proteasome-subunit-rpn13-is-a-novel-ubiquitin-receptor/feed/ 0 Structure and dynamics of two beta-peptides in solution from molecular dynamics simulations validated against experiment http://www.medils.org/hr/index.php/archives/2008/07/18/structure-and-dynamics-of-two-beta-peptides-in-solution-from-molecular-dynamics-simulations-validated-against-experiment/ http://www.medils.org/hr/index.php/archives/2008/07/18/structure-and-dynamics-of-two-beta-peptides-in-solution-from-molecular-dynamics-simulations-validated-against-experiment/#comments Fri, 18 Jul 2008 15:56:14 +0000 bojan http://www.medils.org/hr/?p=336 Zagrovic B, Gattin Z, Lau JKC, Huber M & van Gunsteren WF
European Journal of Biophysics, 2008, 37:903-912.

]]> http://www.medils.org/hr/index.php/archives/2008/07/18/structure-and-dynamics-of-two-beta-peptides-in-solution-from-molecular-dynamics-simulations-validated-against-experiment/feed/ 0 Computational Study of the Mechanism and the Relative Free Energies of Binding of Anticholesteremic Inhibitors to Squalene-Hopene Cyclase http://www.medils.org/hr/index.php/archives/2008/04/26/computational-study-of-the-mechanism-and-the-relative-free-energies-of-binding-of-anticholesteremic-inhibitors-to-squalene-hopene-cyclase/ http://www.medils.org/hr/index.php/archives/2008/04/26/computational-study-of-the-mechanism-and-the-relative-free-energies-of-binding-of-anticholesteremic-inhibitors-to-squalene-hopene-cyclase/#comments Sat, 26 Apr 2008 16:23:49 +0000 admin http://www.medils.org/hr/?p=158 Schwab F, Gunsteren WF, Zagrovic B., Biochemistry
2008 47(9):2945-2951.

Computational Study of the Mechanism and the Relative Free Energies of Binding of Anticholesteremic Inhibitors to Squalene-Hopene Cyclase

]]> http://www.medils.org/hr/index.php/archives/2008/04/26/computational-study-of-the-mechanism-and-the-relative-free-energies-of-binding-of-anticholesteremic-inhibitors-to-squalene-hopene-cyclase/feed/ 0 Direct visualization of horizontal gene transfer http://www.medils.org/hr/index.php/archives/2008/04/26/direct-visualization-of-horizontal-gene-transfer/ http://www.medils.org/hr/index.php/archives/2008/04/26/direct-visualization-of-horizontal-gene-transfer/#comments Sat, 26 Apr 2008 16:21:09 +0000 admin http://www.medils.org/hr/?p=157 Babic A, Lindner AB, Vulic M, Stewart EJ & Radman M.
Science 319, 1533-1536 (2008).

Direct visualization of horizontal gene transfer

]]> http://www.medils.org/hr/index.php/archives/2008/04/26/direct-visualization-of-horizontal-gene-transfer/feed/ 0 Ubiquitin signals in the NF-kappaB pathway http://www.medils.org/hr/index.php/archives/2007/12/29/ubiquitin-signals-in-the-nf-kappab-pathway/ http://www.medils.org/hr/index.php/archives/2007/12/29/ubiquitin-signals-in-the-nf-kappab-pathway/#comments Sat, 29 Dec 2007 21:19:35 +0000 admin http://localhost/wordpress/index.php/archives/2007/12/29/ubiquitin-signals-in-the-nf-kappab-pathway/ Terzić J, Marinović-Terzić I, Ikeda F, Đikić I.
Biochem Soc Trans. 2007 Oct;35(Pt 5):942-5.

]]> http://www.medils.org/hr/index.php/archives/2007/12/29/ubiquitin-signals-in-the-nf-kappab-pathway/feed/ 0 Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases http://www.medils.org/hr/index.php/archives/2007/12/29/suppressor-of-t-cell-receptor-signalling-1-and-2-differentially-regulate-endocytosis-and-signalling-of-receptor-tyrosine-kinases/ http://www.medils.org/hr/index.php/archives/2007/12/29/suppressor-of-t-cell-receptor-signalling-1-and-2-differentially-regulate-endocytosis-and-signalling-of-receptor-tyrosine-kinases/#comments Sat, 29 Dec 2007 21:05:24 +0000 admin http://localhost/wordpress/index.php/archives/2007/03/01/suppressor-of-t-cell-receptor-signalling-1-and-2-differentially-regulate-endocytosis-and-signalling-of-receptor-tyrosine-kinases/ Raguž J, Wagner S, Đikić I, Höller D.
FEBS Lett. 2007 Oct 2;581(24):4767-72.

]]> http://www.medils.org/hr/index.php/archives/2007/12/29/suppressor-of-t-cell-receptor-signalling-1-and-2-differentially-regulate-endocytosis-and-signalling-of-receptor-tyrosine-kinases/feed/ 0 Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes http://www.medils.org/hr/index.php/archives/2007/12/15/involvement-of-the-ubiquitin-like-domain-of-tbk1ikk-i-kinases-in-regulation-of-ifn-inducible-genes/ http://www.medils.org/hr/index.php/archives/2007/12/15/involvement-of-the-ubiquitin-like-domain-of-tbk1ikk-i-kinases-in-regulation-of-ifn-inducible-genes/#comments Sat, 15 Dec 2007 20:45:59 +0000 admin http://localhost/wordpress/index.php/archives/2007/12/15/involvement-of-the-ubiquitin-like-domain-of-tbk1ikk-i-kinases-in-regulation-of-ifn-inducible-genes/ Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, Akira S, Dötsch V, Đikić I.
EMBO J 2007; 26(14):3451-62

Abstract

TANK-binding kinase 1 (TBK1/NAK/T2K) and I-kB Kinase (IKK-i/IKK-e)play important roles in the regulation of interferon (IFN)-inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram-negative bacteria leads to activation of TBK1 or IKK-i, which in turn phos phorylates the transcription factors, IFN-regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK-i and identified a ubiquitin-like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK-i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN-b or RANTES promoters. The importance of the ULD of TBK1 in LPS- or poly (I:C)-stimulated IFN-b production was demonstrated by reconstitution experiments in TBK1-IKK-i-deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK-i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways.

Involvement of the ubiquitin-like domain

]]> http://www.medils.org/hr/index.php/archives/2007/12/15/involvement-of-the-ubiquitin-like-domain-of-tbk1ikk-i-kinases-in-regulation-of-ifn-inducible-genes/feed/ 0 Ubiquitin and ubiquitin-like proteins in cancer pathogenesis http://www.medils.org/hr/index.php/archives/2006/12/28/ubiquitin-and-ubiquitin-like-proteins-in-cancer-pathogenesis/ http://www.medils.org/hr/index.php/archives/2006/12/28/ubiquitin-and-ubiquitin-like-proteins-in-cancer-pathogenesis/#comments Thu, 28 Dec 2006 20:44:22 +0000 admin http://localhost/wordpress/index.php/archives/2006/12/28/ubiquitin-and-ubiquitin-like-proteins-in-cancer-pathogenesis/ Höller D, Hecker C, Đikić I.
Nat Rev Cancer (2006), 6:776-88

Abstract

Ubiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, the cell cycle and DNA repair. It is becoming apparent that the deregulation of ubiquitin pathways results in the development of human diseases, including many types of tumours. Here we summarize the common principles and specific features of ubiquitin and Ubls in the regulation of cancer-relevant pathways, and discuss new strategies to target ubiquitin signalling in drug discovery.

Ubiquitin and ubiquitin-like proteins

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