Ubiquitylation and cell signaling
Kaisa Haglund, Ivan Đikić
The EMBO Journal, (2005), 24:3353 - 3359
Abstract. Ubiquitylation is an emerging mechanism implicated in a variety of nonproteolytic cellular functions. The attachment of a single ubiquitin (Ub) or poly-Ub (lysine63) chains to proteins control gene transcription, DNA repair and replication, intracellular traficking and virus budding. In these processes, protein ubiquitylation exhibits inducibility, reversibility and recognition by specialized domains, features similar to protein phosphorylation, which enable Ub to act as a signaling device. Here, we highlight several recent examples on how Ub regulates signaling and how signaling regulates ubiquitylation during physiological and pathological cellular processes.