Interaction of natural substances with cellular target proteins (prof. dr. Herwig Gutzeit, TU Dresden, Germany)
November 20th 2008, 4 pm, large lecture hall at MedILS
Natural substances may interact with numerous target proteins in human cells. For the flavonoid quercetin a method has been developed which allows the identification of unknown target proteins. The target proteins that have been of particular interest to us include the cytoskeletal proteins actin and tubulin and their associated motor proteins. New inhibitors for these proteins have been identified and the effect of the inhibitors studied in various cellular test systems. Possible medical applications will be discussed.