Mechanisms of neurodegeneration

Mutant huntingtin protein (shown as QQQ) causes neurodegeneration by disrupting the function of transcriptional activators (Sp1, CREB) and coactivators (TAF4) (Dunah et al. Science, 2002), and general transcription factors (TFIIF) (Zhai et al, Cell, 2005). Interference with CREB-mediated transcription leads to downregulation of PGC-1alpha and subsequent mitochondrial dysfunction and neurodegeneration (Cui et al, Cell, 2006).

Group leaders

Dimitri Krainc, prof. dr.
Janoš Terzić, prof. dr.

Group students

Marija Usenović, PhD student

Dinko Relković, postdoctoral researcher

Kristina Orešić, postdoctoral researcher

Vinko Palada, student

Collaborators

Dr. Borut Peterlin, University of Ljubljana, Slovenia
Dr. Olaf Riess, University of Tuebingen, Germany
Dr. Christine Klein, University of Luebeck, Germany
Dr. Alexis Brice, University of Paris, France
Dr. Ron Shamir, Tel Aviv University
Dr. Naoko Tanese, New York University, USA
Dr. Ai Yamamoto, Columbia University, USA
Dr. Robert Tjian, University of California, Berkeley, USA
Dr. Anne C. Hart, Harvard Medical School, Boston, USA