ALBA synchrotron and CALIPSOplus:

“A common mechanism of bacterial and human cell death: identification and characterization of cytotoxic protein oligomers leading to permeabilization of the cellular membranes” (2019)

Principal investigator: Katarina Trajkovic

Participants: Katarina Trajkovic, Guillaume Combes, Miroslav Radman, Tanja Ducic

Project description: In this project, we used Fourier Transform Infrared (FTIR) microscopy and spectroscopy to follow the formation of oligomers and fibrils by oxidatively damaged proteins, and to correlate the appearance of such structures with apoptotic and necrotic cell death in mammalian cells exposed to oxidative stress.