Interaction Proteomics and Chemical Approaches to Understanding Cell Signalling Pathways
Research in our lab is focused on protein-protein interactions (PPIs), with a particular interest in disease progression due to altered signalling pathways. We examine how proteins involved in these signalling pathways interact with each other, and try to understand how impaired PPIs lead to numerous human diseases such as lung cancer, pancreatic cancer, breast cancer, brain cancer and aging. To achieve this, we combine cellular, biochemical, and proteomics approaches with chemical genomics and bioinformatics. In close collaboration with medicinal chemists and clinical investigators, our lab investigates the molecular mechanisms behind challenging, unexplained observations on drugs and on pathological events. The ultimate goal of our studies is to link detailed mechanistic understanding of altered signalling pathways to patient biology.