Scientist details

• Name: Igor Štagljar
• E-mail: igor.stagljar@medils.hr
• Biography: Curriculum vitae
• LinkedIn: LinkedIn profile page
• Work group: Cancer Signalling & Therapeutics

Publications at MedILS

• CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system doi.org/10.15252/msb.202110629
• D154Q Mutation does not Alter KRAS Dimerization PMID: 34896362 DOI: 10.1016/j.jmb.2021.167392
• Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling doi.org/10.1016/j.jmb.2021.167283
• Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells doi.org/10.1016/j.jmb.2021.167294
• Drugging the undruggable proteins in cancer: A systems biology approach. doi.org/10.1016/j.cbpa.2021.07.004
• Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches doi.org/10.1038/s41388-021-01841-2
• Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis
• A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies ,https://doi.org/10.1038/s41467-021-22102-6 O
• Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae, G3 (Bethesda). 2020 Jul 8: g3.401468.2020. DOI: 10.1534/g3.120.401468 PMID: 32641451
• REEP5 depletion causes sarco(endo)plasmic reticulum vacuolization and cardiac functional defects, Nature Communication 11 (1) 569, PMID 32075961.
• Split Intein Mediated Protein Ligation (SIMPL), a method for detecting protein-protein interactions and their inhibition, Nature Communications 2020 May 15;11(1): 2440. doi: 10.1038/s41467-020-16299-1 PMID: 32415080
• Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nat Commun. 2020 Jan 24;11(1):499. doi: 10.1038/s41467-019-14224-9. PMID: 31980649; PMCID: PMC6981206.
• A drug discovery platform to identify compounds that inhibit EGFR triple mutants
• Highly Combinatorial Genetic Interaction Analysis Reveals a Multi-Drug Transporter Influence Network
• Saraon P, Grozavu I, Stagljar I. Testing cancer inhibitors at scale. Nat Biomed Eng. 2018 Apr;2(4):203-204. doi: 10.1038/s41551-018-0226-x. PubMed PMID: 30936440.
• Identification and Functional Testing of Novel Interacting Protein Partners for the Stress Sensors Wsc1p and Mid2p of Saccharomyces cerevisiae. G3 (Bethesda). 2019 Feb 7. pii: g3.200985.2018. doi: 10.1534/g3.118.200985. [Epub ahead of print] PubMed PMID: 30733383