Scientist details

• Name: Miroslav Radman
• E-mail: miroslav.radman@medils.hr
• Phone: +385 21 555 600 (621)
• Biography: Curriculum vitae

Publications at MedILS

• Speciation of Genes and Genomes: Conservation of DNA Polymorphism by Barriers to Recombination Raised by Mismatch Repair System doi.org/10.3389/fgene.2022.803690
• Functionalized Au15 nanoclusters as luminescent probes for protein carbonylation detection Communications Chemistry 14 May 2021. doi.org/10.1038/s42004-021-00497-z
• Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases ,doi: 10.3325/cmj.2020.61.159
• 13. Combes, G.F., Pellay, F.X. and Radman, M., 2020. Common cause and mechanism for all pathologies of aging?. Medecine Sciences: M/S, 36(12), pp.1129-1134. PMID: 33296629
• Ecobiological approach to research regarding ageing and diseases. Eur J Dermatol. 2019;29(S1):11–14. doi:10.1684/ejd.2019.3534
• Protein damage, ageing and age-related diseases Open Biol. 2019;9(3):180249. doi:10.1098/rsob.180249
• Cellular parabiosis and the latency of age-related diseases Open Biol. 2019;9(3):180250. doi:10.1098/rsob.180250
• In situ visualization of carbonylation and its co-localization with proteins, lipids, DNA and RNA in Caenorhabditis elegans : Free Radic Biol Med. 2016 Nov 10. pii: S0891-5849(16)31029-2. doi: 10.1016/j.freeradbiomed.2016.11.004
• Death by UVC Light Correlates with Protein Damage in Isogenic Human Tumor Cells: Primary Tumor SW480 versus its Metastasis SW620. Journal of Proteomics and Computational Biology (2016), 2 (1): 12.
• Decreasing translation error rate in Escherichia coli increases protein function. BMC Biotechnol 2016; 16 (1): 28.
• Protein damage, radiation sensitivity and aging DOI: 10.1016/j.dnarep.2016.05.025 PMID: 27264559
• Mismatch repair earns Nobel Prize in Chemistry 2015 to Paul Modrich for a biochemical tour de force. / DNA Repair 37 (2016) A22–A28
• Structural basis of protein oxidation resistance: a lysozyme study. Plos One 2014; 9: e101642.
• Phenotypic and genetic consequences of protein damage. Plos Genetics 2013; 9(9): e1003810.
• Biology of Extreme Radiation Resistance: The Way of Deinococcus radiodurans. Cold Spring Harb Perspect Biol. 2013; 5(7).
• [Aging: the chemistry of a flexible biological clock]. Med Sci (Paris). 2012 Mar;28(3):231-3. doi: 10.1051/medsci/2012283001. Epub 2012 Apr 6. French. PubMed PMID:
• Extreme anti-oxidant protection against ionizing radiation in bdelloid rotifers. Proc Natl Acad Sci U S A. 2012;109(7): 2354-2357.
• Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repair. Nucleic Acids Research, 2012, Vol. 40, No. 9 3929–3938
• Oxidative stress resistance in Deinococcus radiodurans. Microbiol Mol Biol Rev. 2011;75(1):133-91.
• Seeing mutations in living cells. Curr Biol. 2010;20(16):1432-7.
• Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans. Proc Natl Acad Sci U S A. 2010; 107(32): 14373-14377.
• Unstructured hydrophilic sequences in prokaryotic proteomes correlate with dehydration tolerance and host association. J Mol Biol 402: 775-82. (2010)
• RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans. DNA Repair 9: 1151-1161. (2010)
• "Recombination and replication in DNA repair of heavily irradiated Deinococcus radiodurans", Cell (2009) 136:1044-1055; IF 31.3
• The lambda red proteins promote efficient ecombination between diverged sequences: implications for bacteriophage genome mosaicism. PLoS Genet. 2008 May 2;4(5):e1000065. doi: 10.1371/journal.pgen.1000065. PubMed PMID: 18451987; PubMed Central PMCID: PMC2327257.
• Direct visualization of horizontal gene transfer. Science. 2008 Mar 14;319(5869):1533-6. doi: 10.1126/science.1153498. PubMed PMID: 18339941.
• The frequency and structure of recombinant products is determined by the cellular level of MutL. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8935-40. Epub 2007 May 14. PubMed PMID: 17502621; PubMed Central PMCID: PMC1885606
• Reassembly of shattered chromosomes in Deinococcus radiodurans. Nature. 2006 Oct 5;443(7111):569-73. Epub 2006 Sep 27. PubMed PMID: 17006450
• Generation of DNA-free Escherichia coli cells by 2-aminopurine requires mismatch repair and nonmethylated DNA. J Bacteriol. 2006 Jan;188(1):339-42. PubMed PMID: 16352851; PubMed Central PMCID: PMC1317583
• Guidelines: From artificial evolution to computational evolution: a research agenda. Nat Rev Genet. 2006 Sep;7(9):729-35. Epub 2006 Aug 8. PubMed PMID: 16894364
• Specialized DNA polymerases, cellular survival, and the genesis of mutations. Science. 2002 May 31;296(5573):1627-30. Review. PubMed PMID: 12040171.
• Mutation, recombination, and incipient speciation of bacteria in the laboratory. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7348-51. PubMed PMID: 10377417; PubMed Central PMCID: PMC22088.
• Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science. 1997 Oct 3;278(5335):128-30. PubMed PMID: 9311918.
• Role of mutator alleles in adaptive evolution. Nature. 1997 Jun 12;387(6634):700-2. PubMed PMID: 9192893.
• Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell. 1995 Jul 28;82(2):321-30. PubMed PMID: 7628020
• Interspecies gene exchange in bacteria: the role of SOS and mismatch repair systems in evolution of species. Cell. 1995 Feb 10;80(3):507-15. PubMed PMID: 7859291
• Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes. Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):1075-9. PubMed PMID: 1736289; PubMed Central PMCID: PMC48388.
• The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature. 1989 Nov 23;342(6248):396-401. PubMed PMID: 2555716.
• Mismatch repair and recombination in E. coli. Cell. 1987 Aug 14;50(4):621-6. PubMed PMID: 2955904.
• Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction. Proc Natl Acad Sci U S A. 1980 Feb;77(2):1063-7. PubMed PMID: 6987663; PubMed Central PMCID: PMC348424.
• An endonuclease from Escherichia coli that introduces single polynucleotide chain scissions in ultraviolet-irradiated DNA. J Biol Chem. 1976 Mar 10;251(5):1438-45. PubMed PMID: 3498.
• SOS repair hypothesis: phenomenology of an inducible DNA repair which is accompanied by mutagenesis. Basic Life Sci. 1975;5A:355-67. Review. PubMed PMID: 1103845.