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Miroslav Radman - Founder & scientific director
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Name: Miroslav Radman
E-mail:
miroslav.radman@medils.hr
Phone: +385 21 555 600 (621)
Biography:
Curriculum vitae
Publications at MedILS
Speciation of Genes and Genomes: Conservation of DNA Polymorphism by Barriers to Recombination Raised by Mismatch Repair System doi.org/10.3389/fgene.2022.803690
Functionalized Au15 nanoclusters as luminescent probes for protein carbonylation detection Communications Chemistry 14 May 2021. doi.org/10.1038/s42004-021-00497-z
Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases ,doi: 10.3325/cmj.2020.61.159
13. Combes, G.F., Pellay, F.X. and Radman, M., 2020. Common cause and mechanism for all pathologies of aging?. Medecine Sciences: M/S, 36(12), pp.1129-1134. PMID: 33296629
Ecobiological approach to research regarding ageing and diseases. Eur J Dermatol. 2019;29(S1):11–14. doi:10.1684/ejd.2019.3534
Protein damage, ageing and age-related diseases Open Biol. 2019;9(3):180249. doi:10.1098/rsob.180249
Cellular parabiosis and the latency of age-related diseases Open Biol. 2019;9(3):180250. doi:10.1098/rsob.180250
In situ visualization of carbonylation and its co-localization with proteins, lipids, DNA and RNA in Caenorhabditis elegans : Free Radic Biol Med. 2016 Nov 10. pii: S0891-5849(16)31029-2. doi: 10.1016/j.freeradbiomed.2016.11.004
Death by UVC Light Correlates with Protein Damage in Isogenic Human Tumor Cells: Primary Tumor SW480 versus its Metastasis SW620. Journal of Proteomics and Computational Biology (2016), 2 (1): 12.
Decreasing translation error rate in Escherichia coli increases protein function. BMC Biotechnol 2016; 16 (1): 28.
Protein damage, radiation sensitivity and aging DOI: 10.1016/j.dnarep.2016.05.025 PMID: 27264559
Mismatch repair earns Nobel Prize in Chemistry 2015 to Paul Modrich for a biochemical tour de force. / DNA Repair 37 (2016) A22–A28
Structural basis of protein oxidation resistance: a lysozyme study. Plos One 2014; 9: e101642.
Phenotypic and genetic consequences of protein damage. Plos Genetics 2013; 9(9): e1003810.
Biology of Extreme Radiation Resistance: The Way of Deinococcus radiodurans. Cold Spring Harb Perspect Biol. 2013; 5(7).
[Aging: the chemistry of a flexible biological clock]. Med Sci (Paris). 2012 Mar;28(3):231-3. doi: 10.1051/medsci/2012283001. Epub 2012 Apr 6. French. PubMed PMID:
Extreme anti-oxidant protection against ionizing radiation in bdelloid rotifers. Proc Natl Acad Sci U S A. 2012;109(7): 2354-2357.
Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repair. Nucleic Acids Research, 2012, Vol. 40, No. 9 3929–3938
Oxidative stress resistance in Deinococcus radiodurans. Microbiol Mol Biol Rev. 2011;75(1):133-91.
Seeing mutations in living cells. Curr Biol. 2010;20(16):1432-7.
Protein damage and death by radiation in Escherichia coli and Deinococcus radiodurans. Proc Natl Acad Sci U S A. 2010; 107(32): 14373-14377.
Unstructured hydrophilic sequences in prokaryotic proteomes correlate with dehydration tolerance and host association. J Mol Biol 402: 775-82. (2010)
RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans. DNA Repair 9: 1151-1161. (2010)
"Recombination and replication in DNA repair of heavily irradiated Deinococcus radiodurans", Cell (2009) 136:1044-1055; IF 31.3
The lambda red proteins promote efficient ecombination between diverged sequences: implications for bacteriophage genome mosaicism. PLoS Genet. 2008 May 2;4(5):e1000065. doi: 10.1371/journal.pgen.1000065. PubMed PMID: 18451987; PubMed Central PMCID: PMC2327257.
Direct visualization of horizontal gene transfer. Science. 2008 Mar 14;319(5869):1533-6. doi: 10.1126/science.1153498. PubMed PMID: 18339941.
The frequency and structure of recombinant products is determined by the cellular level of MutL. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8935-40. Epub 2007 May 14. PubMed PMID: 17502621; PubMed Central PMCID: PMC1885606
Reassembly of shattered chromosomes in Deinococcus radiodurans. Nature. 2006 Oct 5;443(7111):569-73. Epub 2006 Sep 27. PubMed PMID: 17006450
Generation of DNA-free Escherichia coli cells by 2-aminopurine requires mismatch repair and nonmethylated DNA. J Bacteriol. 2006 Jan;188(1):339-42. PubMed PMID: 16352851; PubMed Central PMCID: PMC1317583
Guidelines: From artificial evolution to computational evolution: a research agenda. Nat Rev Genet. 2006 Sep;7(9):729-35. Epub 2006 Aug 8. PubMed PMID: 16894364
Specialized DNA polymerases, cellular survival, and the genesis of mutations. Science. 2002 May 31;296(5573):1627-30. Review. PubMed PMID: 12040171.
Mutation, recombination, and incipient speciation of bacteria in the laboratory. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7348-51. PubMed PMID: 10377417; PubMed Central PMCID: PMC22088.
Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science. 1997 Oct 3;278(5335):128-30. PubMed PMID: 9311918.
Role of mutator alleles in adaptive evolution. Nature. 1997 Jun 12;387(6634):700-2. PubMed PMID: 9192893.
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell. 1995 Jul 28;82(2):321-30. PubMed PMID: 7628020
Interspecies gene exchange in bacteria: the role of SOS and mismatch repair systems in evolution of species. Cell. 1995 Feb 10;80(3):507-15. PubMed PMID: 7859291
Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes. Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):1075-9. PubMed PMID: 1736289; PubMed Central PMCID: PMC48388.
The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature. 1989 Nov 23;342(6248):396-401. PubMed PMID: 2555716.
Mismatch repair and recombination in E. coli. Cell. 1987 Aug 14;50(4):621-6. PubMed PMID: 2955904.
Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction. Proc Natl Acad Sci U S A. 1980 Feb;77(2):1063-7. PubMed PMID: 6987663; PubMed Central PMCID: PMC348424.
An endonuclease from Escherichia coli that introduces single polynucleotide chain scissions in ultraviolet-irradiated DNA. J Biol Chem. 1976 Mar 10;251(5):1438-45. PubMed PMID: 3498.
SOS repair hypothesis: phenomenology of an inducible DNA repair which is accompanied by mutagenesis. Basic Life Sci. 1975;5A:355-67. Review. PubMed PMID: 1103845.
Miroslav Radman - Founder & scientific director
Groups
Biology of robustness
Skin eco-biology and biochemistry / NAOS-ILS lab
Identification of aging targets
Identification of new molecules and others approaches
Rejuvenation molecules screening
Cancer Signalling & Therapeutics
Publications
Scientists
IMPACT OBSERVATORY
Biophysics PhD programme
Icast
STIM
Alumni
Probing protein carbonylation
Macromolecular homeostasis in aging
What is the role of protein stability and chaperones in longevity
What is the involvement of the mRNA quality control in cellular fitness and aging
How do some proteins avoid oxidation? Is protein oxidation a cooperative process where initial oxidation events would facilitate further deterioration?
Ubiquitin and cancer
Inflammation and cancer
Computational biophysics of macromolecules
Biophysics and bioinformatics
Mechanisms of neurodegeneration
Genetics of Death in Yeast
Intercellular Communication in Aging and Disease
Proteomics Research Group
Preventive and Regenerative Medicine
Sleep apnea
Cellular rejuvenation and clinical impact (CCL)
New paths for next-generation anti-aging approaches
Laboratory for Translational research